Abstract: Squamous epithelial hyperplasia diseases contribute to the biggest part of tumor\|like lesions of the eye.  Many squamous epithelial hyperplasia diseases are caused by virus as pathogen. Human papilla virus(HPV) suppresses the apoptosis of keratinocytes and enhances the hyperplasia of keratinocytes through early protein coding region thus causes the onset of squamous epithelial papilloma, verruca vulgaris and keratoacanthoma. HPV\|DNA can be detected in the lesion of those diseases by PCR. Currently the interferon has been applied into the treatment of the above diseases and acquired reasonable effectiveness in long\|term follow\|ups. Serological positive of human immunodeficiency virus can remarkably raise the morbidity of conjunctival and corneal intraepithelial neoplasm and squamous cell carcinoma. However the pathogenesis remains unknown. The apoptosis of keratinocytes can be suppressed  by the mollascus contagiosum virus coded protein so as to  promote the onset of tumor. However no treatment is available. (Int Rev Ophthalmol, 2014, 38: 212-216)